Anti-Mouse Fc epsilon Receptor I alpha (FceR1) SAFIRE Purified

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Anti-Mouse Fc epsilon Receptor I alpha (FceR1) SAFIRE Purified

货号:84112-25-100,84112-25-500

规格:100 μg,500 μg

价格:1587,3575

产品类型:抗体和染料

品牌:Biogems

物种:人

宿主:小鼠

抗体亚型:IgG

荧光染料:Purified

Catalogue Number :84112-25

Description

The MAR-1 antibody reacts with the Fc epsilon Receptor I alpha chain (FceRIa), a transmembrane protein member of the Ig superfamily. This chain, together with a beta chain and two gamma chains form a tetrameric complex that supports IgE-mediated signaling and subsequent release of chemical mediators of allergy and immediate hypersensitivity. FceR1a is upregulated in the presence of IgE on those cell types which express it, such as Mast cells and Basophils.

The MAR-1 antibody is widely used both in flow cytometry and for depletion of cells in vitro / in vivo.

Additional Information

Clone

MAR-1

Format:

SAFIRE Purified

Applications

FC, FA, IHC, IP

Reactivity

Mouse

Isotype:

Armenian Hamster IgG

Research Interest:Innate Immunity
Cell Type:Monocytes and Macrophages

Preperation:

The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

Formulation:

Phosphate-buffered aqueous solution, ph7.2.

References:

Joncker, N. T., Fernandez, N. C., Treiner, E., Vivier, E., & Raulet, D. H. (2009). NK cell responsiveness is tuned commensurate with the number of inhibitory receptors for self-MHC class I: the rheostat model.The Journal of Immunology,182(8), 4572-4580.

Obata, K., Mukai, K., Tsujimura, Y., Ishiwata, K., Kawano, Y., Minegishi, Y., ... & Karasuyama, H. (2007). Basophils are essential initiators of a novel type of chronic allergic inflammation.Blood,110(3), 913-920.

Arinobu, Y., Iwasaki, H., Gurish, M. F., Mizuno, S. I., Shigematsu, H., Ozawa, H., ... & Akashi, K. (2005). Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis.Proceedings of the National Academy of Sciences of the United States of America,102(50), 18105-18110.

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