CD71 (Transferrin Receptor) Monoclonal Antibody (OKT9 (OKT-9)), APC

货号：17-0719-41,17-0719-42

规格：25 Tests,100 Tests

价格：925,1968

产品类型：流式抗体

品牌：Thermo Fisher

物种：人

宿主：小鼠

抗体亚型：IgG

克隆号：OKT9 (OKT-9)

荧光染料：APC

抗体类型:	单抗	同型对照：	Mouse IgG1 kappa Isotype Control, APC, eBioscience™
免疫原性：		用法：	5uL（0.06µg）/test(Flow）

Description: The OKT9 monoclonal antibody reacts with human CD71, a 170-180 kDa type II transmembrane protein. CD71, the transferrin receptor, exists as a homodimer on the cell surface and is essential for cellular growth. CD71 is expressed by immature proliferating cells and at low levels on resting mature lymphocytes. Antigen or mitogen stimulation of T and B cells upregulates the expression of CD71.Applications Reported: This OKT9 (OKT-9) antibody has been reported for use in flow cytometric analysis.Applications Tested: This OKT9 (OKT-9) antibody has been pre-titrated and tested by flow cytometric analysis of stimulated human peripheral blood cells. This can be used at 5 µL (0.06 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser.Filtration: 0.2 µm post-manufacturing filtered.Background/Target InformationCellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients.For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

数据

CD71 (Transferrin Receptor) Antibody (17-0719-42) in Flow Staining of 3-day anti-CD3/CD28-stimulated normal human peripheral blood cells with Mouse IgG1 kappa Isotype Control APC (Product # 17-4714-81) (blue histogram) or Anti-Human CD71 (Transferrin Receptor) APC (purple histogram). Total viable cells were used for analysis.

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参考文献：

1. PloS oneEDAG promotes the expansion and survival of human CD34+ cells."17-0719 was used in Flow cytometry/Cell sorting to provide novel insight into EDAG in regulation of expansion and survival of human hematopoietic stem/progenitor cells."AuthorsZhao K,Zheng WW,Dong XM,Yin RH,Gao R,Li X,Liu JF,Zhan YQ,Yu M,Chen H,Ge CH,Ning HM,Yang XM,Li CY2. Nature communicationsGenetically engineered red cells expressing single domain camelid antibodies confer long-term protection against botulinum neurotoxin.By clicking the link above, you will be redirected to the Benchsci website.Disclaimer3. Stem cells (Dayton, Ohio)Activation of KLF1 Enhances the Differentiation and Maturation of Red Blood Cells from Human Pluripotent Stem Cells."17-0719 was used in Flow cytometry/Cell sorting to investigate the role of KLF1 in maturation of red blood cells."AuthorsYang CT,Ma R,Axton RA,Jackson M,Taylor AH,Fidanza A,Marenah L,Frayne J,Mountford JC,Forrester LM4. NaturePPAR-α and glucocorticoid receptor synergize to promote erythroid progenitor self-renewal.By clicking the link above, you will be redirected to the Benchsci website.Disclaimer5. BMC genomicsDECKO: Single-oligo, dual-CRISPR deletion of genomic elements including long non-coding RNAs.By clicking the link above, you will be redirected to the Benchsci website.Disclaimer

技术参数

产品应用 FlOW

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