CD1d Monoclonal Antibody (1B1), Functional Grade, eBioscience™/CD1d 单克隆 (1B1), 功能抗体, eBioscience™

货号：16-0011-82,16-0011-85,16-0011-38,16-0011-025,16-0011-050

规格：100 µg,500 µg,5 mg,25 mg,50 mg

价格：1752,3496,24089,72266,120443

产品类型：流式抗体

品牌：eBioscience

抗原：CD1d

物种：小鼠

宿主：大鼠

抗体亚型：IgG2b, kappa

克隆号：1B1

荧光染料：其它

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类型:	一抗(功能抗体）	同型对照：	Rat IgG2b kappa Isotype Control (eB149/10H5), Functional Grade, eBioscience™
浓度：	1 mg/mL	用法：	1.0 µg/test（Flow）;Assay-Dependent（功能检测）

产品详细信息Description: The 1B1 monoclonal antibody reacts with mouse CD1d, a 48 kDa glycoprotein with structural homology to MHC class I molecules. While similar to MHC Class I, CD1d associates with beta2m, functionally CD1d is similar to MHC Class II. 1B1 detects CD1d at varying levels on mouse leukocytes. 1B1 detects beta2m associated CD1d.Applications Reported: The 1B1 antibody has been reported for use in flow cytometric analysis. 1B1 has also been reported in in vivo and in vitro studies.靶标信息CD1d is a 49 kDa heavy chain associated with Beta 2 microglobulin on cortical thymocytes. Beta 2 microglobulin independent expression of CD1d has also been demonstrated on human intestinal epithelial cells. CD1d is the sole group 2 member of the CD1 family of major histocompatibility (MHC) like glycoproteins. The CD1d gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by the CD1d gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail. Diseases associated with CD1D include Mycobacterium Malmoense and Autoimmune Disease.仅用于科研。不用于诊断过程。

数据

CD1d Antibody (16-0011-82) in FlowStaining of BALB/c splenocytes with 1.0 µg of Rat IgG2b K Isotype Control Functional Grade Purified (Product # 16-4031-81) (open histogram), or 1.0 µg of Anti-Mouse CD1d Functional Grade Purified (filled histogram) followed by Anti-Rat IgG FITC (Product # 11-4811-85).Total viable cells were used for analysis.

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参考文献：

流式1.PloS oneMultiple functional therapeutic effects of TnP: A small stable synthetic peptide derived from fish venom in a mouse model of multiple sclerosis."Published figure using CD1d monoclonal antibody (Product # 16-0011-82) in Flow Cytometry"2.Nature communicationsNFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells."Published figure using CD1d monoclonal antibody (Product # 16-0011-82) in Flow Cytometry"3.ImmunityNuclear export of the NF-κB inhibitor IκBα is required for proper B cell and secondary lymphoid tissue formation."Published figure using CD1d monoclonal antibody (Product # 16-0011-82) in Flow Cytometry"WB4.PloS oneFHL1 reduces dystrophy in transgenic mice overexpressing FSHD muscular dystrophy region gene 1 (FRG1)."Published figure using CD1d monoclonal antibody (Product # 16-0011-82) in Western Blot"中和5.BMC gastroenterologyImpaired liver regeneration is associated with reduced cyclin B1 in natural killer T cell-deficient mice."16-0011 was used in Blocking experiments to study the role of natural killer T cells in liver regeneration, and their association with cyclin B1 and IL-6."AuthorsBen Ya'acov A,Meir H,Zolotaryova L,Ilan Y,Shteyer E6.Proceedings of the National Academy of Sciences of the United States of AmericaInvariant natural killer T cells act as an extravascular cytotoxic barrier for joint-invading Lyme Borrelia."16-0011 was used in Blocking experiments to demonstrate a novel, critical extravascular invariant natural killer T cell-mediated mechanism of immune surveillance in joints."AuthorsLee WY,Sanz MJ,Wong CH,Hardy PO,Salman-Dilgimen A,Moriarty TJ,Chaconas G,Marques A,Krawetz R,Mody CH,Kubes P

技术参数

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