CD142 Monoclonal Antibody (HTF-1), Functional Grade, eBioscience™/CD142 单克隆 (HTF-1), 功能抗体, eBioscience™
货号：16-1429-82,16-1429-85,16-1429-38,16-1429-025 ,16-1429-050
规格：500 µg,500 µg,5 mg,25 mg,50 mg
价格：1632,3615,24089,72266,120443
产品类型：流式抗体
品牌：eBioscience
抗原：CD142
物种：人
宿主：小鼠
抗体亚型：IgG1, kappa
克隆号：HTF-1
荧光染料：其它
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类型: | 一抗(功能抗体） | 同型对照： | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), Functional Grade, eBioscience™ |
浓度： | 1 mg/mL | 用法： | 0.25 µg/test（Flow）;Assay-Dependent（IF）;Assay-Dependent（功能检测）;Assay-Dependent（ICC） |
产品详细信息Description: This HTF-1 monoclonal antibody reacts with human CD142, which is also known as Tissue Factor. Expression of this type I transmembrane glycoprotein on endothelial cells, monocytes, macrophages, and platelets can be induced by inflammatory mediators (e.g., LPS, IL-1b, TNFa, PMA, or endotoxin). On the other hand, CD142 is expressed constitutively by some tumor cells (e.g., lung, pancreatic, breast, and colon) and non-immune tissues such as the vasculature, central nervous system, kidney, epithelia, and placenta. Studies have also suggested that CD142 exists as a soluble form that circulates in blood. CD142 initiates blood coagulation by associating with and activating the circulating factors VII and VIIa.The HTF-1 antibody has been reported to exhibit blocking activity.Applications Reported: This HTF-1 antibody has been reported for use in functional assays, flow cytometric analysis, western blotting, and immunocytochemistry.Applications Tested: This HTF-1 antibody has been tested by flow cytometric analysis of stimulated normal human peripheral blood cells. This can be used at less than or equal to 0.25 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Filtration: 0.2 µm post-manufacturing filtered.Purity: Greater than 90%, as determined by SDS-PAGE.Endotoxin Level: Less than 0.001 ng/µg antibody, as determined by LAL assay.Aggregation: Less than 10%, as determined by HPLC.靶标信息This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described.仅用于科研。不用于诊断过程。未经明确授权不得转售。
二抗
荧光二抗
免疫组化一抗
标签抗体
WB
1.Scientific reportsDifferent Potential of Extracellular Vesicles to Support Thrombin Generation: Contributions of Phosphatidylserine, Tissue Factor, and Cellular Origin."16-1429 was used in Western Blotting to provide evidence that irrespective of their cellular origin, EVs support the propagation of coagulation via the exposure of phosphatidylserine.."AuthorsTripisciano C,Weiss R,Eichhorn T,Spittler A,Heuser T,Fischer MB,Weber V
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