CD13 Monoclonal Antibody (WM-15 (WM15)), FITC, eBioscience™

货号：11-0138-42

规格：100 Tests

价格：1855

产品类型：流式抗体

品牌：eBioscience

抗原：CD13

物种：人

宿主：小鼠

抗体亚型：IgG

克隆号：WM-15 (WM15)

荧光染料：FITC

抗体类型:	流式抗体	同型对照：	Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), FITC, eBioscience™
浓度：	5 µL/Test	用法：	5 μL(1 μg)/test (Flow)

产品详细信息Description: The WM-15 monoclonal antibody reacts with human CD13, also known as aminopeptidase N. CD13 is a transmembrane ectoenzyme occurring on monocytes and granulocytes but not lymphocytes in blood. It is also reportedly on a wide variety of cells and in a wide variety of tissues, including endothelial cells, epithelial cells, fibroblasts, kidney proximal tubules, intestine, and placenta. CD13 is reported to have many different functions including degradation of enkephalins and endorphins, terminal degradation of peptides, amino acid scavenging, antigen processing, and adhesion and migration of cells.Applications Reported: The WM-15 (WM15) antibody) has been reported for use in flow cytometric analysis.Applications Tested: This WM-15 (WM15) antibody has been pre-titrated and tested by flow cytometric analysis of lysed whole blood. This can be used at 5 µL (1 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser.Filtration: 0.2 µm post-manufacturing filtered. 靶标信息CD13 (ANPEP) is a 150-170 kDa type II transmembrane zinc-binding ectopeptidase expressed on various cell types. CD13 is a metalloprotease that preferentially catalyzes removal of neutral amino acids from small peptides, thus activating or inactivating bioactive peptides. CD13 also has a role in extracellular matrix degradation, antigen processing and signal transduction, is important in inflammatory responses, regulates intercellular contact, cell motility and vascularization. CD13 is expressed by granulocytes, monocytes, myeloid leukemia cells, and is involved in protection of leukemic cells against apoptosis and its expression associated with poor prognosis of carcinomas. CD13 functions as an aminopeptidase enzyme and is also alpha receptor for coronavirus.

数据

CD13 Antibody (11-0138-42) in Flow Staining of normal human peripheral blood cells with Mouse IgG1 K Isotype Control FITC (Product # 11-4714-42) (blue histogram) or Anti-Human CD13 FITC (purple histogram). Cells in the granulocyte gate were used for analysis. CD13 Antibody (11-0138-42) The Journal of clinical investigation 2015 -Published figure using CD13 monoclonal antibody (Product # 11-0138-42)

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参考文献：

1. Nature communications SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4.2. Scientific reports Wogonin reversed resistant human myelogenous leukemia cells via inhibiting Nrf2 signaling by Stat3/NF-κB inactivation.3. The Journal of clinical investigation ZIC2-dependent OCT4 activation drives self-renewal of human liver cancer stem cells.4. Nature communications LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells.5. The Journal of clinical investigation ZIC2-dependent OCT4 activation drives self-renewal of human liver cancer stem cells.

技术参数

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