Anti-Mouse LPAM-1 Biotin

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Anti-Mouse LPAM-1 Biotin

货号:83212-30-25,83212-30-100

规格:25ug,100 μg

价格:416,990

产品类型:流式抗体

品牌:Biogems

物种:人

宿主:小鼠

抗体亚型:IgG

荧光染料:Purified

Catalogue Number :83212-30

Description

The DATK32 monoclonal antibody specifically reacts with an epitoPEof the Mouseα4β7 integrin (LPAM-1). The two subunits of the LPAM-1 heterodimer are the 154 kDa α4 and the 130 kDa β7. Most mature lymphocytes, a subset of bone marrow cells, and some of the thymic cells express the α4β7 integrin heterodimer. α4β7 enhances the transendothelial migration of lymphocytes, and interacts with several ligands (fibronectin, CD106, and MAdCAM-1). The interaction of DATK32 with the α4β7 induces the α4β7-dependent lymphocyte aggregation and inhibits LPAM-1-dediated cell adhesion.

Additional Information

Clone

DATK32

Format:

Biotin

Applications

FC

Reactivity

Mouse

Isotype:

Rat IgG2a, kappa

Research Interest:Adaptive Immunity,Angiogenesis
Cell Type:B Cells,NK and NKT Cells,T Cells

Preperation:

The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Formulation:

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

References:

Andrew, D. P., Berlin, C., Honda, S., Yoshino, T., Hamann, A., Holzmann, B., ... & Butcher, E. C. (1994). Distinct but overlapping epitopes are involved in alpha 4 beta 7-mediated adhesion to vascular cell adhesion molecule-1, mucosal addressin-1, fibronectin, and lymphocyte aggregation.The Journal of Immunology,153(9), 3847-3861.

Berlin, C., Berg, E. L., Briskin, M. J., Andrew, D. P., Kilshaw, P. J., Holzmann, B., ... & Butcher, E. C. (1993). α4β7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1.Cell,74(1), 185-195.

Rivera-Nieves, J., Olson, T., Bamias, G., Bruce, A., Solga, M., Knight, R. F., ... & Ley, K. (2005). L-selectin, α4β1, and α4β7 integrins participate in CD4+ T cell recruitment to chronically inflamed small intestine.The Journal of Immunology,174(4), 2343-2352.

技术参数
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